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Long-term complications of diabetes develop gradually. the longer you have diabetes — and the less controlled your blood sugar — the higher the risk of complications. eventually, diabetes complications may be disabling or even life-threatening. possible complications include: 1. cardiovascular disease. diabetes dramatically increases the risk of various cardiovascular problems, including coronary artery disease with chest pain (angina), heart attack, stroke and narrowing of arteries (atherosc Another relationship between arginine and diabetes is the amino acid's ability to stimulate insulin release, in addition to initiating the release of growth hormone and other body chemicals. some research suggests that the relationship between arginine and diabetes is more apparent in patients diagnosed with the type 1 condition. Diabetic neuropathy can cause a number of serious complications, including: 1. loss of a toe, foot or leg. nerve damage can make you lose feeling in your feet. foot ...